These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Boronate-immobilized cellulose nanofiber-reinforced cellulose microspheres for pH-dependent adsorption of glycoproteins. Author: Li S, Qiao L, Liang C, Zhao L, Du K. Journal: Carbohydr Polym; 2022 Dec 15; 298():120068. PubMed ID: 36241267. Abstract: High strength and excellent selectivity are two important aspects of porous cellulose microspheres as adsorbents for protein separation. For this purpose, self-reinforced all-cellulose microspheres (SCMs) with high strength were fabricated using natural cellulose nanofibers (CNFs) as fillers and then immobilized via 3-aminophenylboronic acids as affinity ligands for selective enrichment of glycoproteins. In particular, the inherent stiffness of entrapped CNFs endowed SCMs with more inflexibility, because the stress can be efficiently transferred from the network of SCMs to the stiff CNFs during the separation process. Besides, SCMs, as an all-cellulose material with homogenous surface chemistry and pore structure characteristics, are more suitable as supports for adsorbents. Finally, the SCMs were immobilized with 3-aminophenylboronic acids (BA/EPI-SCMs) and tested their performance in affinity adsorption of glycoproteins. BA/EPI-SCMs showed fast separation, high adsorption amount, and excellent selectivity toward glycoproteins.[Abstract] [Full Text] [Related] [New Search]