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  • Title: A rare case of cerebellar degeneration due to primary Sjogren's syndrome.
    Author: Aveiro M, Cunha RN, Rodrigues T, Domingues J, Aguiar R, Oliveira A.
    Journal: ARP Rheumatol; 2022; 1(3):260-261. PubMed ID: 36242593.
    Abstract:
    Sjogren's syndrome (SS) is an autoimmune pathology which mainly affects salivary and lacrimal glands. Cerebellar degeneration association with SS is very rare, with only a few cases described. The treatment of SS with central nervous system involvement is not consensual. We present a 48-year-old woman with dysarthria, diplopia and ataxia associated with xerostomia. The brain magnetic imaging revealed bilateral cerebellar atrophy. She had antibody positivity for anti-SSA and anti-SSB and minor salivary glands biopsy revealed lymphocytic infiltration. Methylprednisolone, cyclophosphamide and intravenous immunoglobulin yielded no results. Rituximab was initiated with improvement in dysarthria and coordination.
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