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  • Title: Prostaglandin-mediated inhibition of noradrenaline release: V. A comparison of the neuroinhibitory effect of three prostaglandins: E2, I2, and 6-keto-PGF1alpha.
    Author: Wennmalm A.
    Journal: Prostaglandins Med; 1978 Jul; 1(1):49-54. PubMed ID: 362453.
    Abstract:
    The effect of PGE2, PGI2, and 6-keto-PGF1alpha respectively on the contractile response of the isolated, field-stimulated guinea pig vas deferens was investigated. All three PGs were capable of inhibiting the contractile responses of the vas deferens, but the concentrations required varied considerably: PGE2 was about 700 times more active than PGI2 and about 4600 times more active than 6-keto-PGF1alpha in this respect. It is suggested that PGI2, although formed in tissues with sympathetic innervation, does not play a physiological role as inhibitor of sympathetic transmitter release.
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