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  • Title: Distribution of trimipramine and its major metabolites in a fatal overdose case.
    Author: Fraser AD, Isner AF, Perry RA.
    Journal: J Anal Toxicol; 1987; 11(4):168-70. PubMed ID: 3626529.
    Abstract:
    A fatality following ingestion of the tricyclic antidepressant trimipramine (Surmontil) is described. Quantitation was performed by high-performance liquid chromatography. Trimipramine and desmethyltrimipramine concentrations were 4.8 and 2.1 mg/L, respectively, in postmortem blood. The concentration of trimipramine, desmethyltrimipramine, and their respective 2-hydroxy metabolites were also measured in liver and urine. Analysis of gastric contents revealed a tricyclic antidepressant drug. These findings are compared to previously published reports of trimipramine-related fatalities.
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