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  • Title: The antifeedant and antifungal cryptic metabolites isolated from tobacco endophytes induced by host medium and coculture.
    Author: Chen JX, Xia DD, Yang XQ, Yang YB, Ding ZT.
    Journal: Fitoterapia; 2022 Nov; 163():105335. PubMed ID: 36272702.
    Abstract:
    Four new cryptic metabolites including one fumagillol derivative (2), one cyclohexenone derivative (4), one 10-membered lactone (5), and one natural 4-epi-brefeldin C (8), along with seven known compounds were found from isogenesis endophytes Aspergillus fumigatus, Penicillium janthinellum, Nigrospora sp., and Stagonosporopsis sp. induced by host Nicotiana tabacum medium and co-culture. The structures were determined mainly by spectroscopic methods, including extensive 1D, 2D NMR, MS techniques, ECD calculation, and Mosher's method. Compound 2 possessed a novel 1, 3-dioxetane residue and cyclohexane-containing terpenoid skeleton. Compounds 2, 4-7 and 10 showed significant antifungal activities against the plant pathogen Nigrospora sp. with MICs of 1 μg/mL. 2, 4, 5-7, and 10 indicated antifungal activities against Penicillium janthinellum, Aspergillus fumigatus, Phomopsis sp., and Alternaria sp. with MICs ≤8 μg/mL. Compounds 2, 6-8, and 10 (50 μg/cm2) and microbial fermentation extracts (100 μg/cm2) showed antifeedant activities against silkworms with feeding deterrence indices of 21-100%.
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