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  • Title: A pilot study comparing myelin measurements from myelin water imaging and 11C-PIB PET in multiple sclerosis.
    Author: Vavasour IM, Vafai N, Beauchemin P, Kanjilal C, Badalan A, Shahinfard E, Laule C, Li DK, Traboulsee A, Sossi V, Kolind SH, Carruthers RL.
    Journal: Mult Scler Relat Disord; 2022 Dec; 68():104238. PubMed ID: 36274287.
    Abstract:
    MRI-based myelin water fraction (MWF) and PET-based Pittsburgh compound B (PiB) imaging both have potential to measure myelin in multiple sclerosis (MS). We characterised the differences in MWF and PiB binding in MS lesions relative to normal-appearing white matter and assessed the correlation between MWF and PiB binding in 11 MS participants and 3 healthy controls within 14 white matter regions of interest. Both PiB binding and MWF were reduced in MS lesions relative to NAWM, and a modest within subject correlation between MWF and PiB binding was found. This pilot study shows that MWF and PET-PiB provide different information about myelin loss in MS.
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