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  • Title: The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats.
    Author: Tokola O, Lindén IB, Tenhunen R.
    Journal: Pharmacol Toxicol; 1987 Jul; 61(1):75-8. PubMed ID: 3628186.
    Abstract:
    Biochemical disorders caused by allylisopropylacetamide in various animal species resemble human acute intermittent porphyria. The antiporphyrogenic efficacy and potency of haem arginate, a new haem compound, were compared with those of haematin in experimental porphyria of rats. Both haem arginate and haematin dose-dependently decreased the urinary excretions of porphyrin precursors. They inhibited significantly the induction of hepatic delta-aminola-evulinic acid synthase. Haem arginate and haematin could restore the activity of haem oxygenase and after higher doses they increased the activity. The dose-effect relationships of the two haem compounds were demonstrated.
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