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  • Title: Direct Minisci-Type C-H Amidation of Purine Bases.
    Author: Mooney DT, Moore PR, Lee AL.
    Journal: Org Lett; 2022 Nov 04; 24(43):8008-8013. PubMed ID: 36285836.
    Abstract:
    A method for the C-H carboxyamidation of purines has been developed that is capable of directly installing primary, secondary, and tertiary amides. Previous Minisci-type investigations on purines were limited to alkylations and arylations. Herein, we present the first method for the direct C-H amidation of a wide range of purines: xanthine, guanine, and adenine structures, including guanosine- and adenosine-type nucleosides. The Minisci-type reaction is also metal-free, cheap, operationally simple, scalable, and applicable to late-stage functionalizations of biologically important molecules.
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