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  • Title: Triiodothyronine potentiation of antidepressant-induced reversal of learned helplessness in rats.
    Author: Brochet DM, Martin P, Soubrié P, Simon P.
    Journal: Psychiatry Res; 1987 Jul; 21(3):267-75. PubMed ID: 3628611.
    Abstract:
    Several clinical investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or therapeutic response to antidepressants. The present report describes that the reversal by antidepressants (imipramine, desipramine, and nomifensine) of depressive-like behavior in rats (escape deficits produced by previous exposure to uncontrollable stress) was significantly hastened in animals given daily triiodothyronine (T3). The learned helplessness paradigm might be a useful model for approaching in animals the neurohormonal correlates of affective disorders and the neurobiochemical bases of the reported T3 enhancement of antidepressants.
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