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  • Title: MR image-guided P-31 MR spectroscopy in the evaluation of brain tumor treatment.
    Author: Segebarth CM, Balériaux DF, Arnold DL, Luyten PR, den Hollander JA.
    Journal: Radiology; 1987 Oct; 165(1):215-9. PubMed ID: 3628774.
    Abstract:
    Magnetic resonance (MR) image-guided phosphorus-31 MR spectra have been obtained from in situ brain tumors. The volumes of interest used for spectroscopy were defined from hydrogen-1 MR images. Direct comparisons were possible between normal and abnormal tissue, since P-31 spectra from different parts of the brain could be measured in a single examination. P-31 MR spectra of the tumors often showed abnormally high concentrations of phosphomonoesters and low concentrations of phosphocreatines. The effects of pharmacotherapy and radiation therapy were studied in three patients; in each of these cases changes were observed in the P-31 spectra of the tumor. The correlation between MR imaging and P-31 MR spectroscopy was essential for the interpretations of these results.
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