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  • Title: [Activity of key enzymes of gluconeogenesis in the liver and corticosterone levels of the blood of thymectomized rats].
    Author: Zozuliakova SV, Podosinnikov IS, Chukhlovina ML, Zalkind LG, Polushkina LI.
    Journal: Ukr Biokhim Zh (1978); 1987; 59(4):20-5. PubMed ID: 3629725.
    Abstract:
    Thymectomized rats have been studied with the aim to determine the activity of gluconeogenesis key enzymes (phosphoenol pyruvate carboxykinase, fructose-1.6-diphosphatase, glucose-6-phosphatase), the glycogen content in the liver, the corticosterone level in blood and electrolytes concentration in erythrocytes and blood plasma. The activity of glucose-6-phosphatase and the glycogen content in the liver as well as the corticosterone level in the rat blood are shown to diminish after thymectomy. Changes are found in the electrolytic composition of blood as well as in the activity of key enzyme of the pentose cycle in erythrocytes. The data obtained indicate that thymectomy in rats is followed by the pronounced biochemical shifts induced by the thymus hormone deficiency and disturbance of interrelations in the system of neuroendocrine regulation.
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