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  • Title: Silver Nanoparticles Application as a Colorimetric Probe for the Spectrophotometric Determination of Hyoscine Butylbromide in Pharmaceutical Formulations.
    Author: Hasan LI, Jabbar HS.
    Journal: J AOAC Int; 2023 Mar 01; 106(2):285-295. PubMed ID: 36303319.
    Abstract:
    BACKGROUND: Hyoscine butylbromide is used as an antispasmodic in treating peptic ulcers, gastritis, and various disorders of the gastrointestinal tract that are characterized by spasms. It has also found employment for the relief of spasmodic conditions of the bile duct and urinary tract and for the treatment of dysmenorrhea. OBJECTIVE: In this study, the application of silver nanoparticles (Ag NPs) as a colorimetric probe for the fast, selective, and simple determination of hyoscine butylbromide was described. METHODS: The proposed method was based on the Ag NPs aggregation induced by their interaction with the cited drug. This interaction produced a color change from yellow to colorless measured at 405 nm. RESULTS: The method linear concentration range was 0.10-50.0 µg/mL with a correlation equation (y = 0.0132 x + 0.3174), correlation coefficient of 0.9981, and quantification limits of 0.091 µg/mL. A thorough investigation was done to validate the method's analytical performance, and the findings were satisfactory. With great accuracy and precision, this approach was used to identify the medication in pharmaceutical tablet samples with recovery percentages ranging from 96.20 to 98.10%. CONCLUSIONS: Since there are no critical reaction conditions or solvent extraction involved in the described method, it is distinguished by its simplicity. The results were quite consistent with those attained using the approved standard method. HIGHLIGHTS: Simple, fast, and sensitive colorimetric probe developed for determination of hyoscine butylbromide in pharmaceutical formulations.
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