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  • Title: Intrathecal administration of netilmicin in gentamicin-resistant ventriculitis.
    Author: Donauer E, Drumm G, Moringlane J, Ostertag C, Kivelitz R.
    Journal: Acta Neurochir (Wien); 1987; 86(3-4):83-8. PubMed ID: 3630784.
    Abstract:
    In ventriculitis caused by Gentamicin-resistant staphylococcus aureus and staphylococcus epidermidis, Netilmicin was administered intrathecally to 19 patients under continuous control of the Netilmicin concentration in cerebro-spinal fluid (CSF). This therapy was able to bring these otherwise lethal infections under control, usually within 10 days. Pharmacokinetic studies with different doses have shown that doses of 2 X 3 mg are to be recommended in moderately severe cases of ventriculitis, and in most severe infections 3 X 3 mg daily intraventricularly for adults. In infants daily intraventricular injections of 2 X 0.4-0.5 mg Netilmicin are a sufficient dose to produce an effective antibiotic concentration level.
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