These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Near-Infrared Spectroscopy Enables Arthroscopic Histologic Grading of Human Knee Articular Cartilage.
    Author: Sarin JK, Prakash M, Shaikh R, Torniainen J, Joukainen A, Kröger H, Afara IO, Töyräs J.
    Journal: Arthrosc Sports Med Rehabil; 2022 Oct; 4(5):e1767-e1775. PubMed ID: 36312728.
    Abstract:
    PURPOSE: To develop the means to estimate cartilage histologic grades and proteoglycan content in ex vivo arthroscopy using near-infrared spectroscopy (NIRS). METHODS: In this experimental study, arthroscopic NIR spectral measurements were performed on both knees of 9 human cadavers, followed by osteochondral block extraction and in vitro measurements: reacquisition of spectra and reference measurements (proteoglycan content, and three histologic scores). A hybrid model, combining principal component analysis and linear mixed-effects model (PCA-LME), was trained for each reference to investigate its relationship with in vitro NIR spectra. The performance of the PCA-LME model was validated with ex vivo spectra before and after the exclusion of outlying spectra. Model performance was evaluated based on Spearman rank correlation (ρ) and root-mean-square error (RMSE). RESULTS: The PCA-LME models performed well (independent test: average ρ = 0.668, RMSE = 0.892, P < .001) in the prediction of the reference measurements based on in vitro data. The performance on ex vivo arthroscopic data was poorer but improved substantially after outlier exclusion (independent test: average ρ = 0.462 to 0.614, RMSE = 1.078 to 0.950, P = .019 to .008). CONCLUSIONS: NIRS is capable of nondestructive evaluation of cartilage integrity (i.e., histologic scores and proteoglycan content) under similar conditions as in clinical arthroscopy. CLINICAL RELEVANCE: There are clear clinical benefits to the accurate assessment of cartilage lesions in arthroscopy. Visual grading is the current standard of care. However, optical techniques, such as NIRS, may provide a more objective assessment of cartilage damage.
    [Abstract] [Full Text] [Related] [New Search]