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  • Title: [The synergistic effect of human recombinant TNF in combination with various anti-cancer drugs].
    Author: Yamauchi N, Watanabe N, Ohtsuka Y, Sone H, Neda H, Maeda M, Niitsu Y, Urushizaki I.
    Journal: Gan To Kagaku Ryoho; 1987 Sep; 14(9):2730-4. PubMed ID: 3631972.
    Abstract:
    The synergistic effect of human recombinant TNF in combination with various anti-cancer drugs was examined in vitro. In vitro treatment of L-M cells with TNF and mitomycin C (MMC), adriamycin (ADM), cytosine arabinoside (Ara-C), actinomycin D (ACD), daunorubicin (DM), cisplatin (CDDP), vincristine (VCR), or 5-fluorouracil (5-FU) revealed a synergistic cytotoxicity. However, the combination of TNF with bleomycin (BLM) failed to show such a synergistic effect.
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