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  • Title: Conversion of leukotriene C4 to leukotriene D4 by a cell-surface enzyme of rat macrophages.
    Author: Nagaoka I, Yamashita T.
    Journal: Biochem Biophys Res Commun; 1987 Aug 31; 147(1):282-7. PubMed ID: 3632671.
    Abstract:
    Leukotriene (LT) C4-metabolizing enzyme was studied using rat leukocytes. Neutrophils and lymphocytes hardly metabolized LTC4, whereas macrophages rapidly converted LTC4 to LTD4. The LTC4-metabolizing enzyme of macrophages was present in the membrane fraction but not in the nuclear, granular and cytosol fractions. When macrophages were modified chemically with diazotized sulfanilic acid, a poorly permeant reagent which inactivates cell-surface enzymes selectively, the LTC4-metabolizing activity of macrophages decreased significantly (greater than 90%). These findings suggest that rat macrophages possess the LTC4-metabolizing enzyme which converts LTC4 to LTD4, on the cell surface membrane.
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