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  • Title: Inhibitory effect of carp muscle trypsin inhibitor on mammalian pancreatic proteinases.
    Author: Toyohara H, Makinodan Y.
    Journal: Comp Biochem Physiol B; 1986; 83(2):283-5. PubMed ID: 3633776.
    Abstract:
    Carp muscle trypsin inhibitor showed an inhibitory effect on bovine trypsin, bovine alpha-chymotrypsin and porcine elastase in a non-competitive, competitive and competitive manner, respectively. The inhibitor formed a stable complex with the above proteinases which was not dissociated in the presence of 2-mercaptoethanol and SDS. The true target proteinase for carp muscle trypsin inhibitor, as yet unknown, seems to be an alpha-chymotrypsin- or elastase-like enzyme rather than trypsin, judging from the manner of inhibition.
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