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  • Title: Chiral phosphoric acid-catalyzed dual-ring formation for enantioselective construction of N-N axially chiral 3,3'-bisquinazolinones.
    Author: Pu LY, Zhang YJ, Liu W, Teng F.
    Journal: Chem Commun (Camb); 2022 Nov 24; 58(94):13131-13134. PubMed ID: 36349690.
    Abstract:
    In contrast with the well-developed C-C and C-N axial chirality, research focusing on the catalytically asymmetric synthesis of N-N axially chiral compounds is still limited. As a privileged subunit of many antibiotics, the synthesis of N-N axially chiral 3,3'-bisquinazolinones has not been updated with atroposelective construction. Herein, we firstly report a chiral phosphoric acid-catalyzed dual-ring formation strategy leading to the aforementioned compounds with good chemical yields and enantioselectivities. Notably, metal-free reaction conditions are another advantage of this procedure.
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