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  • Title: Quantitation of chlordiazepoxide and its metabolites in biological fluids by thin-layer chromatography.
    Author: Straughan JL, Cathcart-Rake WF, Shoeman DW, Azarnoff DL.
    Journal: J Chromatogr; 1978 Nov 01; 146(3):473-80. PubMed ID: 363736.
    Abstract:
    Chlordiazepoxide and its 4 major metabolites were assayed after separation by thin-layer chromatography following extraction from biological fluids. The compounds become intensely fluorescent in the presence of red, fuming nitric acid. The resulting compounds are quantitated with a spectrodensitometer with a fluorescent attachment. The sensitivity varies between 0.05 and 0.1 microgram. The coefficient of variation is 1.4% for assays in urine and 6.4% in serum.
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