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  • Title: Injectable polylysine and dextran hydrogels with robust antibacterial and ROS-scavenging activity for wound healing.
    Author: Yang R, Xue W, Liao H, Wu F, Guo H, Zhang W, Wang P, Tan X, Xu H, Chi B.
    Journal: Int J Biol Macromol; 2022 Dec 31; 223(Pt A):950-960. PubMed ID: 36375676.
    Abstract:
    Cutaneous wound management remains a major concern due to uncontrolled inflammation and bacterial infection in clinical care. A desirable hydrogel dressing with antibacterial and antioxidative properties can drive wound healing by inhibiting infection and inflammation. Herein, a multifunctional hydrogel based on polylysine-graft-cysteine (EPL-SH)/oxidized dextran (ODex) was fabricated for promoting skin tissue regeneration. The engineered hydrogel possessed versatile properties including tunable gelation time (60-300 s), typical rheological behavior, suitable swelling and degradation progress, injectable and self-healing ability. The unique hydrogels also displayed promising tissue adhesiveness, high cell affinity, excellent antioxidant and antimicrobial activity. Furthermore, the in vivo full-thickness skin defect experiment demonstrated the simple-to-implement injectable hydrogels could significantly promoting wound healing by improving the collagen deposition and angiogenesis. The manufacture of our multifunctional hydrogels dressing affords a new strategy for improving efficacy of cutaneous wound treatment.
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