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  • Title: <b>The control of carpel determinacy pathway leads to sex determination</b> <b>in cucurbits</b>
    Author: Zhang S, Tan FQ, Chung CH, Slavkovic F, Devani RS, Troadec C, Marcel F, Morin H, Camps C, Gomez Roldan MV, Benhamed M, Dogimont C, Boualem A, Bendahmane A.
    Journal: Science; 2022 Nov 04; 378(6619):543-549. PubMed ID: 36378960.
    Abstract:
    Male and female unisexual flowers evolved from hermaphroditic ancestors, and control of flower sex is useful for plant breeding. We isolated a female-to-male sex transition mutant in melon and identified the causal gene as the carpel identity gene <i>CRABS CLAW (CRC)</i>. We show that the master regulator of sex determination in cucurbits, the transcription factor <i>WIP1</i> whose expression orchestrates male flower development, recruits the corepressor TOPLESS to the <i>CRC</i> promoter to suppress its expression through histone deacetylation. Impairing TOPLESS-WIP1 physical interaction leads to <i>CRC</i> expression, carpel determination, and consequently the expression of the stamina inhibitor, the aminocyclopropane-1-carboxylic acid synthase 7 (<i>CmACS7</i>), leading to female flower development. Our findings suggest that sex genes evolved to interfere with flower meristematic function, leading to unisexual flower development.
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