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  • Title: Antibody response in cattle and rabbits to early antigens of malignant catarrhal fever virus in cultured cells.
    Author: Rossiter PB, Mushi EZ, Plowright W.
    Journal: Res Vet Sci; 1978 Sep; 25(2):207-10. PubMed ID: 364579.
    Abstract:
    Cytosine arabinoside (Ara-C) inhibited the production of late antigens and of infectious virus in monolayers of bovine kidney cells infected with the high-passage, WC-11 strain of malignant catarrhal fever virus. Early antigens were not affected. Using hyperimmune and acute-phase sera from cattle and rabbits in indirect immunofluorescence tests, it was shown that Ara-C treated cultures contained two early antigens; one was diffuse and distributed throughout the cells, the other was particulate and intranuclear. Antibody to early antigens developed later and attained lower titres in infected animals, especially rabbits; only hyperimmune sera reacted with the diffuse early antigen.
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