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  • Title: Catalytic enantioselective desymmetrization of meso-aziridines.
    Author: Yang PJ, Chai Z.
    Journal: Org Biomol Chem; 2023 Jan 18; 21(3):465-478. PubMed ID: 36508282.
    Abstract:
    As a type of readily available small strained-ring heterocycle, meso-aziridines may undergo catalytic desymmetrizing transformations to empower the rapid construction of diverse nitrogen-containing structures bearing contiguous stereocenters, which have great relevance in natural product synthesis, drug development and the design and synthesis of chiral catalysts/ligands for asymmetric catalysis. This review outlines the advances achieved in the catalytic asymmetric desymmetrization of meso aziridines and highlights some promising avenues for further work in this realm.
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