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  • Title: Mollicellins: mutagenic and antibacterial mycotoxins.
    Author: Stark AA, Kobbe B, Matsuo D, Büchi G, Wogan GN, Demain AL.
    Journal: Appl Environ Microbiol; 1978 Sep; 36(3):412-20. PubMed ID: 365106.
    Abstract:
    Eight mollicellins (depsidones) were assayed for mutagenicity and antibacterial activity in Salmonella/microsome tests involving histidine reversion and forward mutation to 8-azaguanine resistance. Two of them, mollicellins C and E, which contain a 3-methylbutenoic acid moiety, were mutagenic and bactericidal for Salmonella typhimurium in the absence of microsomes. Mollicellins D and F, each containing a chlorine atom, were bactericidal but not mutagenic. The mutagenic activity was completely abolished and the antibiotic activity was greatly reduced by coincubation with rat liver microsomes.
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