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  • Title: Zinc pyrovanadate nanorods with excellent peroxidase-like activity at physiological pH for the colorimetric assay of H2O2 and epinephrine.
    Author: Liu Y, Hao P, Liu Z, Li G, Fan G, Xie M, Liu Q.
    Journal: Analyst; 2023 Jan 16; 148(2):269-277. PubMed ID: 36510856.
    Abstract:
    Exploring highly active peroxidase mimics at physiological pH is important for the construction of efficient and convenient colorimetric sensing platforms for detecting small biomolecules. In this work, prepared zinc pyrovanadate (Zn3V2O7(OH)2·2H2O) nanorods exhibit excellent peroxidase-like activity, which is verified by the fast oxidation of colorless 3,3',5,5'-tetramethylbenzidine (TMB) into a blue product (oxTMB) by H2O2 at physiological pH (pH = 7) in 2 min. In addition, the catalytic behaviors of Zn3V2O7(OH)2·2H2O as a peroxidase-like nanozyme conform to the Michaelis-Menten equation. Scavenger experiments prove that the catalytic activity of Zn3V2O7(OH)2·2H2O is ascribed to ˙O2- radicals generated in the process of catalysis. Based on the peroxidase-like activity of the Zn3V2O7(OH)2·2H2O nanozyme, a fast and convenient colorimetric sensor has been constructed to detect H2O2 and epinephrine (EP) under physiological pH. The detection limit of EP is as low as 0.26 μM. In addition, the feasibility of the proposed sensor has been validated to detect H2O2 in milk and EP in serum.
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