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  • Title: Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata.
    Author: Tan L, Otsuki K, Zhang M, Kikuchi T, Okayasu M, Azumaya I, Zhou D, Li N, Huang L, Chen CH, Li W.
    Journal: J Nat Prod; 2022 Dec 23; 85(12):2856-2864. PubMed ID: 36516989.
    Abstract:
    From the whole plant of Daphne pedunculata, 12 macrocyclic daphnane diterpenoids, including six new compounds, daphnepedunins A-F (1-4, 9, and 10), were isolated. Their structures were elucidated by physiochemical and spectroscopic data analysis, the modified Mosher's method, and X-ray crystallography. The isolated compounds were evaluated for anti-HIV activity against HIV-1 infection in MT4 cells and showed significant anti-HIV activity with IC50 values of 36.3-994 nM. A consideration of the anti-HIV activity of these compounds provided further insight into the structure-activity relationships of macrocyclic daphnane diterpenoids.
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