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  • Title: Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children.
    Author: Ogita S, Tsuto T, Tokiwa K, Takahashi T.
    Journal: Br J Surg; 1987 Aug; 74(8):690-1. PubMed ID: 3651773.
    Abstract:
    Nine patients with cystic hygroma were treated with a new sclerosing therapy consisting of intracystic injection of OK-432 (group A Streptococcus pyogenes of human origin). Favourable results including complete regression in eight patients and marked regression in one were observed within 2-3 months without serious side-effects except for fever of 2-3 days' duration and local inflammatory reaction lasting for 3-4 days. Local inflammatory reaction did not cause any damage to the overlying skin and did not lead to scar formation.
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