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  • Title: Convergence of hepatoportal osmotic and cardiovascular signals on preoptic thermosensitive neurons.
    Author: Koga H, Hori T, Inoue T, Kiyohara T, Nakashima T.
    Journal: Brain Res Bull; 1987 Jul; 19(1):109-13. PubMed ID: 3651835.
    Abstract:
    Effects of hepatoportal osmotic stimuli and changes in arterial blood pressure were studied on the neuronal activity of 24 thermosensitive and 47 thermally insensitive neurons of the preoptic and anterior hypothalamus (PO/AH) in the urethane-anesthetized rat. Infusion of hypertonic (3% NaCl, 9% mannitol) or hypotonic (water) solutions into the hepatic portal vein changes the activity in 59% of thermosensitive neurons and 13% of thermally insensitive neurons but the injection into the femoral vein did not. Changes in blood pressure induced by intravenous injection of vasoactive drugs altered the activity of thermosensitive neurons (75%) and thermally insensitive neurons (32%). Neurons having dual sensitivity to both osmotic and blood pressure were more frequently found among thermosensitive neurons (10/24) than among thermally insensitive neurons (4/47), chi 2(1) = 11.03, p less than 0.001. The convergence of osmotic and baro/volaemic information on thermosensitive neurons may provide explanations for thermoregulatory changes observed during dehydration and acute hypotension.
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