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  • Title: Biologic therapies for chronic obstructive pulmonary disease.
    Author: Matera MG, Calzetta L, Cazzola M, Ora J, Rogliani P.
    Journal: Expert Opin Biol Ther; 2023 Feb; 23(2):163-173. PubMed ID: 36527286.
    Abstract:
    INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a disorder characterized by a complicated chronic inflammatory response that is resistant to corticosteroid therapy. As a result, there is a critical need for effective anti-inflammatory medications to treat people with COPD. Using monoclonal antibodies (mAbs) to inhibit cytokines and chemokines or their receptors could be a potential approach to treating the inflammatory component of COPD. AREAS COVERED: The therapeutic potential that some of these mAbs might have in COPD is reviewed. EXPERT OPINION: No mAb directed against cytokines or chemokines has shown any therapeutic impact in COPD patients, apart from mAbs targeting the IL-5 pathway that appear to have statistically significant, albeit weak, effect in patients with eosinophilic COPD. This may reflect the complexity of COPD, in which no single cytokine or chemokine has a dominant role. Because the umbrella term COPD encompasses several endotypes with diverse underlying processes, mAbs targeting specific cytokines or chemokines should most likely be evaluated in limited and focused populations.
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