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  • Title: Labetalol, a cross-over double blind controlled trial.
    Author: Sanders GL, Routledge PA, Rao JG, Gales GM, Davies DM, Rawlins MD.
    Journal: Eur J Clin Pharmacol; 1978 Dec 18; 14(5):301-4. PubMed ID: 365543.
    Abstract:
    20 patients (12 female) with moderately severe essential hypertension [blood pressure during placebo treatment 181 +/- 6 (systolic), 107 +/- 3 (diastolic)] completed a double-blind, cross-over dose-titrated comparison of labetalol and methyldopa. Both drugs reduced lying and standing arterial blood pressure to a similar extent, although only labetalol reduced heart rate. Compliance was high (greater than 95%) with both drugs, and the incidence of subjective adverse effects was similar.
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