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  • Title: Routine synthesis of carbon-11-carboxyl-labeled L-dopa.
    Author: Adam MJ, Grierson JR, Ruth TJ, Pedersen K, Pate BD.
    Journal: J Nucl Med; 1987 Oct; 28(10):1599-603. PubMed ID: 3655912.
    Abstract:
    Carbon-11-carboxyl-labeled L-dopa has been synthesized by the modified Bucherer-Strecker method. The reaction mixture was first purified by chiral HPLC followed by deprotection using hydriodic acid. The entire procedure was performed in a remotely operated system which gave the product in 28% radiochemical yield (decay corrected) in an overall synthesis time of 55-60 min.
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