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  • Title: A simple and sensitive determination of histamine and N tau-methylhistamine in biological fluids by high-performance liquid chromatography with electrochemical detection.
    Author: Houdi AA, Crooks PA, Van Loon GR, Schubert CA.
    Journal: J Pharm Sci; 1987 May; 76(5):398-401. PubMed ID: 3656102.
    Abstract:
    The determination of picomolar levels of histamine and its major metabolite, N tau-methylhistamine, in biological fluids was achieved using reversed-phase liquid chromatography coupled with electrochemical detection. A simple sample purification procedure for blood and urine samples was carried out prior to analysis using an Amberlite CG-50 cation-exchange resin, which afforded an excellent recovery of both compounds.
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