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  • Title: Cu-Catalyzed Polychloromethylamination of Styrenes through C(sp3 )-H Bond Cleavage.
    Author: Zhu F, Xue J, Yin P.
    Journal: Chemistry; 2023 Mar 22; 29(17):e202203079. PubMed ID: 36573558.
    Abstract:
    A copper-catalyzed three-component coupling reaction has been developed allowing the rapid building of valuable complex highly functionalized β-polychloromethyl amines from simple styrenes, arylamines, and dichloromethane/chloroform. Using aryldiazonium salts as a radical initiator, a series of corresponding products are obtained with moderate to good yields under a carbon dioxide or nitrogen atmosphere (50 psi). In addition, good functional group tolerance can be observed.
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