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  • Title: Reduction of indomethacin-induced gastrointestinal blood loss by sodium salicylate in man.
    Author: Torgyán S, Ady E, Wagner L, Neumann T, Béres G, Csányi M.
    Journal: Int J Clin Pharmacol Biopharm; 1978 Dec; 16(12):610-1. PubMed ID: 365801.
    Abstract:
    The gastrointestinal bleeding during treatment with indomethacin, aspirin, phenylbutazone and sodium salicylate in healthy human subjects was determined. Gastrointestinal blood loss was determined by the Cr51-labelled erythrocyte method. The method was modified by us. Collected stool was incinerated and radioactivity of ashes was determined. Furthermore, rheumatic patients were treated for 4 weeks with indomethacin alone or with indomethacin combined with sodium salicylate. The gastrointestinal blood loss was determined on the last 4 days of treatment. It was found that blood loss was significantly reduced by combined treatment in comparison to monotherapy with indomethacin, while combined treatment had a marked anti-rheumatic effect.
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