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Title: EFFECT OF IRON ON BONE TISSUE METABOLISM AND THYROID FUNCTION IN CHILDREN LIVING ON RADIOLOGICALLY CONTAMINATED TERRITORIES SINCE THE ChNPP ACCIDENT.
Author: Bazyka DA, Bruslova KM, Lyashenko LO, Pushkariova TI, Tsvetkova NM, Zaitseva AL, Gonchar LO, Yatsemirskyi SM, Lytvynets OL, Tryhlib IV, Boyarskyi VG, Ivanova OM, Horbachiov SG.
Journal: Probl Radiac Med Radiobiol; 2022 Dec; 27():264-275. PubMed ID: 36582094.
Abstract:
OBJECTIVE: To assess the metabolic processes in bone tissue and state of thyroid gland depending on iron metabolism parameters in children of pre-pubertal, pubertal and post-pubertal age, living on radiologically contaminated territories after the ChNPP accident. MATERIALS AND METHODS: Children (n = 119) aged 6 to 18 years were examined and the 4 study groups were formed, featuring the childhood, pre-pubertal, pubertal and post-pubertal life periods. Clinical symptoms, iron metabolism parameters (serum iron (SI) and ferritin (SF) content, transferrin saturation coefficient), parameters of bone tissue metabolism (serum creatinine and alkaline phosphatase (APh)), and amino acid content in urine were taken into account. Functional state of thyroid, titers of antibodies to thyroperoxidase (TPOAb) and thyroglobulin (TgAb) were assayed. Results and their discussion are presented depending on the age of children, biochemical parameters of blood, iron metabolism findings, thyroid gland function and individualized radiation doses. RESULTS: In 13.4 % of pubertal and post-pubertal children an elevated content of SI and SF was observed. APh levels were increased in 20.2 % of children (758.9 ± 16.3 U/l) being directly correlated with SI levels (rs = 0.50; р < 0.01). In 16.3 % of children of pubertal and post-pubertal age, in whom the level of SI was above 27 μmol/l, a direct correlation with serum thyroid-stimulating hormone (TSH) level was established in case of the hormone content above 2.5 mU/l (rs = 0.50; р < 0.05). Serum creatinine level directly correlated with glycine content in urine (rs = 0.70), which is a part of collagen, and inversely correlated with serum APh (rs = -0.47), (р < 0.05). Under the levels of SI higher than (15.1 ± 1.2) μmol/l and SF higher than (87.5 ± 6.4) ng/ml, the TPOAb titer was higher than at lower iron concentrations (U-test = 64.5, р < 0.05). The TgAb titer directly correlated with SI (rs = 0.39) and TSH (rs = 0.81) levels (р < 0.01). The average effective radiation dose in children was (0.75 ± 0.10) mSv. A direct correlation was established between the child's radiation dose and age (rs = 0.33; р < 0.05). CONCLUSIONS: Bone metabolism depends on the age of children, characteristics of pubertal period, excess of iron in the body, and functional state of thyroid system, which is involved in collagen formation and protein metabolism. Meta: otsinyty metabolichni protsesy v kistkoviĭ tkanyni u diteĭ, iaki prozhyvaiut' na radioaktyvno zabrudnenykh terytoriiakh pislia avariï na ChAES, prepubertatnogo, pubertatnogo ta postpubertatnogo viku, stan shchytopodibnoï zalozy zalezhno vid obminu zaliza.Materialy i metody. Obstezheno 119 diteĭ vikom vid 6 do 18 rokiv i sformovano 4 grupy nagliadu (dytiachyĭ vik, prepubertatnyĭ, pubertatnyĭ ta postpubertatnyĭ periody). Vrakhovuvaly klinichnu symptomatyku, obmin zaliza (vmist syrovatkovogo zaliza (SZ) ta ferytynu (SF), koefitsiient nasychennia transferynu), pokaznyky metabolizmu kistkovoï tkanyni (kreatynin, luzhna fosfataza), aminokyslotnyĭ sklad sechi. Vyvchaly funktsional'nyĭ stan shchytopodibnoï zalozy, tytry antytil do tyreoperoksydazy (ATPO) ta tyreoglobulinu (ATTG). Otsinka rezul'tativ doslidzhennia predstavlena zalezhno vid viku diteĭ, biokhimichnykh pokaznykiv krovi, obminu zaliza, funktsiï shchytopodibnoï zalozy ta indyvidualizovanykh doz oprominennia. Rezul'taty. U 13,4 % diteĭ pubertatnogo i postpubertatnogo viku sposterigavsia pidvyshchenyĭ riven' SZ ta SF. U 20,2 % diteĭ rivni LF buly pidvyshcheni (758,9 ± 16,3) od/l i znakhodylys' v priamomu koreliatsiĭnomu zv’iazku z SZ (rs = 0,50; r < 0,01). U 16,3 % diteĭ pubertatnogo ta postpubertatnogo viku, u iakykh riven' SZ buv vyshche 27 mkmol'/l, vstanovleno priamyĭ koreliatsiĭnyĭ zv’iazok z TTG v syrovattsi krovi, za umov vmistu gormona vyshche 2,5 mOd/l (rs = 0,50; r < 0,05). Riven' kreatyninu v syrovattsi krovi znakhodyvsia v priamomu koreliatsiĭnomu zv’iazku z glitsynom v sechi (rs = 0,70), iakyĭ vkhodyt' do skladu kolagenu, ta zvorotnomu koreliatsiĭnomu zv’iazku z LF v syrovattsi krovi (rs = -0,47), (r < 0,05). Za naiavnosti rivnia SZ vyshche (15,1 ± 1,2) mkmol'/l ta SF vyshche (87,5 ± 6,4) ng/ml ATPO buly vyshchi, nizh pry bil'sh nyz'kykh rivniakh zaliza (U emp. = 64,5; r < 0,05). ATTG znakhodylys' v priamiĭ koreliatsiĭniĭ zalezhnosti vid rivnia SZ (rs = 0,39) ta TTG (rs = 0,81), (r < 0,01). Serednia efektyvna doza oprominennia diteĭ dorivniuvala (0,75 ± 0,10) mZv. Namy vstanovleno priamyĭ koreliatsiĭnyĭ zv’iazok mizh dozoiu oprominennia dytyny ta ïï vikom (rs = 0,33; r < 0,05). Vysnovky. Protsesy kistkovogo metabolizmu zalezhat' vid viku diteĭ, osoblyvosteĭ pubertatnogo periodu, nadlyshku zaliza v organizmi ta funktsional'nogo stanu tyreoïdnoï systemy, iaka bere uchast' u formuvanni kolagenu i obmini bilku.

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