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  • Title: FACTORS AFFECTING MECHANISMS OF INCREASED BONE DENSITY FORMATION IN CHILDREN LIVING ON RADIOLOGICALLY CONTAMINATED TERRITORIES AFTER THE ChNPP ACCIDENT.
    Author: Bazyka DA, Bruslova KM, Lyashenko LO, Tsvetkova NM, Pushkariova TI, Galkina SG, Kondrashova VG, Yaroshenko ZS, Gonchar LO, Boyarskyi VG, Charnysh TO, Tryhlib IV, Tsvet LO.
    Journal: Probl Radiac Med Radiobiol; 2022 Dec; 27():276-289. PubMed ID: 36582095.
    Abstract:
    OBJECTIVE: to determine the causes of increased bone mineral density (BMD) based on case history, clinical and laboratory data, including the assay of hormones involved in ossification processes in children, living on radiologically contaminated territories (RCT) after the accident at the ChNPP, compared to the normative BMD patterns. MATERIALS AND METHODS: There were 289 children involved in the study. The 1st group included persons with a BMD above 100 IU, 2nd group - with normative BMD (100-85 IU). Family history of diseases was assessed featuring cancer and endocrine diseases, cholelithiasis, and urolithiasis. Weight of the child at birth, frequency of bone fractures, complaints about osalgia, jaw abnormalities, dental caries, presence or absence of obesity, peripheral blood count, blood biochemical parameters (total protein, creatinine, iron, alkaline phosphatase, calcium), serum pituitary thyroid-stimulating hormone and cortisol were accounted. Children's radiation doses were calculated according to the materials of the «General dosimetric certification of settlements of Ukraine that were exposed to radioactive contamination after the Chornobyl accident». RESULTS: Higher than normative BMD values were found in children after puberty, while normative ones - in puberty (р < 0.001), regardless of gender. A direct correlation between the bone fractures frequency was established in children with increased BMD (р < 0.01). Jaw anomalies and dental caries occurred at that significantly less often than in normative BMD (р > 0.05). A direct correlation was established between the obesity and BMD (р < 0.001).Increased alkaline phosphatase activity was inversely correlated with BMD (rs = -0.21; р < 0.05). In children with elevated BMD a direct correlation was established between the level of iron and endocrine disorders in the family history (р > 0.001). Serum level of cortisol was directly correlated with dental caries (р < 0.05). In children, regardless of BMD value, a direct correlation was established between the radiation dose, age and obesity (р < 0.001). CONCLUSIONS: Higher than normative BMD is accompanied by an increased frequency of bone fractures, jaw abnormalities, metabolic changes in bone tissue and bone tissue hormonal regulation in children, which requires application of pathogenetic therapy for the osteogenesis. Meta: vyznachyty prychyny pidvyshchenoï shchil'nosti kistkovoï tkanyny (ShchKT) na pidstavi danykh anamnezu, kliniko-laboratornoï diagnostyky ta gormonal'noï reguliatsiï protsesiv osteoutvorennia porivniano z normatyvnoiu ShchKT u diteĭ, zhyteliv radioaktyvno zabrudnenykh terytoriĭ, pislia avariï na ChAES. Materialy i metody. Obstezheno 289 diteĭ: do 1-ï grupy uviĭshly patsiienty z ShchKT vyshche 100 um. od.; do 2-ï – z normatyvnoiu ShchKT (100–85 um. od.). Otsiniuvaly zakhvoriuvannia u rodovodi diteĭ (onkologichni ta endokrynni khvoroby, zhovchnokam’ianu ta sechokam’ianu khvoroby). Vrakhovuvaly masu tila pry narodzhenni dytyny, chastotu perelomiv kistok, skargy na osalgiï, anomaliï shchelepy, kariies zubiv, naiavnist' ozhyrinnia, pokaznyky peryferychnoï krovi, biokhimichni pokaznyky krovi (zagal'nyĭ bilok, kreatynin, zalizo, luzhna fosfataza, kal'tsiĭ) ta tyreotropnyĭ gormon gipofizu i kortyzol v syrovattsi krovi. Dozy oprominennia diteĭ rozrakhovuvaly zgidno z materialamy «Zagal'nodozymetrychnoï pasportyzatsiï naselenykh punktiv Ukraïny, iaki zaznaly radioaktyvnogo zabrudnennia pislia Chornobyl's'koï avariï».Rezul'taty. Vyshcha za normatyvnu ShchKT sposterigalas' u diteĭ v postpubertatnomu vitsi, normatyvna – v pubertatnomu periodi (r < 0,001) nezalezhno vid stati dytyny. U diteĭ z pidvyshchenoiu ShchKT vstanovleno priamu koreliatsiĭnu zalezhnist' z chastotoiu perelomiv kistok (r < 0,01). Anomaliï shchelepy ta proiavy kariiesu zubiv zustrichalys' dostovirno ridshe, nizh pry normatyvniĭ ShchKT (r > 0,05). Vstanovleno priamu koreliatsiĭnu zalezhnist' mizh naiavnistiu ozhyrinnia u dytyny ta ShchKT (r < 0,001). Pidvyshchena aktyvnist' luzhnoï fosfatazy zvorotno koreliuvala zi ShchKT (rs = -0,21; r < 0,05). U diteĭ z pidvyshchenoiu ShchKT vstanovleno priamyĭ koreliatsiĭnyĭ zv’iazok mizh rivnem zaliza i naiavnistiu endokrynnoï patologiï u rodovodi (r > 0,001). Riven' kortyzolu v syrovattsi krovi priamo koreliuvav z proiavamy kariiesu zubiv (r < 0,05). U diteĭ nezalezhno vid ShchKT vstanovleno priamyĭ koreliatsiĭnyĭ zv’iazok mizh dozoiu oprominennia, vikom ta naiavnistiu ozhyrinnia (r < 0,001). Vysnovky. Vyshcha za normatyvnu ShchKT suprovodzhuiet'sia pidvyshchenoiu chastotoiu perelomiv kistok u diteĭ, anomaliieiu shchelepy, metabolichnymy zminamy v kistkoviĭ tkanyni ta gormonal'niĭ reguliatsiï, shcho potrebuie zastosuvannia patogenetychnoï terapiï protsesiv osteoutvorennia.
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