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  • Title: Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture.
    Author: Goldberg MP, Pham PC, Choi DW.
    Journal: Neurosci Lett; 1987 Sep 11; 80(1):11-5. PubMed ID: 3658226.
    Abstract:
    The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.
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