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  • Title: Biological characterization of the Bothrops brazili snake venom and its neutralization by Brazilian Bothrops antivenom produced by the Butantan Institute.
    Author: Muniz EG, Sano-Martins IS, Saraiva MDGG, Monteiro WM, Magno ES, Oliveira SS.
    Journal: Toxicon; 2023 Feb; 223():107010. PubMed ID: 36586491.
    Abstract:
    We evaluated the ability of the Bothrops antivenom produced by the Butantan Institute to neutralize the lethal, hemorrhagic, myotoxic and phospholipase A2 activities induced by B. brazili venom from Rondônia state, Brazil, and verified its cross-reactivity against this venom. This antivenom neutralized the cited biological activities. It also showed cross-reactivity with this venom, and preferentially recognized components with a relative mass above 66 kDa. Our results suggest that Brazilian Bothrops antivenom can be used in B. brazili envenomation in this region.
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