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  • Title: [The role of cell membrane damage in the development of hormone-resistant kidney diseases in children].
    Author: Krylov VI, Petrushina AD, Moreva GV, Grannik GK, Durygin AN.
    Journal: Vopr Med Khim; 1987; 33(4):22-4. PubMed ID: 3660735.
    Abstract:
    Distinct increase in content of lysophosphatidyl choline, dehydrocholesterol, decrease in concentration of phosphatidyl ethanolamine simultaneously with high level of diene conjugates and Schiff bases were found in children with hormone-resistant form of nephrotic glomerulonephritis as compared with children suffering from a hormone-dependent form of the disease. Peroxidation of membrane lipids appears to cause a destabilization of cell membranes, which is responsible for development of hormone-resistance.
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