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  • Title: The immediate and long-term effects of applying capsaicin to cutaneous nerves.
    Author: Lynn B.
    Journal: Acta Physiol Hung; 1987; 69(3-4):287-94. PubMed ID: 3661215.
    Abstract:
    Capsaicin has now been shown to have a neurotoxic action on C-fibres in adult rodents and several other mammalian species. In the adult the effect is preferentially on nociceptive C-fibres. The hypoalgesia and loss of neurogenic inflammation that follow capsaicin treatment are likely to be a direct consequence of the C-fibre loss. In addition to its long-term toxic action, capsaicin also has an immediate effect on conduction in nociceptive C-fibres. This action probably produces the short-term hypoalgesia and loss of antidromic plasma extravasation that follow application of capsaicin to peripheral nerves.
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