These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A developed composite hard-gelatin capsules: delayed-release enteric properties.
    Author: Nezhad Mohseni M, Najafpour Darzi G, Ramezani R, Jahani A.
    Journal: Heliyon; 2022 Dec; 8(12):e12265. PubMed ID: 36619422.
    Abstract:
    Present study focused on improvement of the formulation of conventional hard gelatin capsules using gastric acid-resistant polymers. We have utilized the same approach of making conventional drug capsules to develop novel capsules with delayed release properties. For this purpose, delayed-release capsules were produced by improving the formulation of hard gelatin capsules. In addition, the effect of adding intestinal polymers such as Hydroxy propyl methyl cellulose phthalate, Glucomannan, and Polyvinyl alcohol to hard gelatin capsules were investigated. The capsules' release rate was determined. The degradation tests in an acidic environment were performed and the results were recorded. In fact, the delayed-release hard gelatin capsules pass through the stomach with small amount of the drug release; but their shell remains intact and dissolves as it enters the intestine environment. This article shows that enteric polymers with out interactions, only by changing the formulations will have delayed release properties. this makes sensitive drugs pass through stomach environment and have higher absorption.
    [Abstract] [Full Text] [Related] [New Search]