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  • Title: Identification and quantification of 5-hydroxypipecolic acid and hydroxyproline in mammalian brain and blood by selected ion monitoring.
    Author: Miyata T, Okano Y, Nagata-Tanoue J, Ijima-Miyamura S, Iwamura H, Takahama K, Hitoshi T.
    Journal: Anal Biochem; 1987 Jun; 163(2):303-8. PubMed ID: 3661981.
    Abstract:
    A method for the analysis of 5-hydroxypipecolic acid and 4-hydroxyproline in mammalian brain and blood is reported. The identification and quantification of the two hydroxyimino acids were accomplished with gas chromatography/mass spectrometry including a selected ion-monitoring technique following HPLC prepurification. The lower limit of detection for the method is 2 to 10 pmol. The amounts of 5-hydroxypipecolic acid and 4-hydroxyproline in blood were 20 to 30 pmol/ml and 3 to 6 nmol/ml, respectively. Their concentrations in the rabbit whole brain were determined to be 5 and 120 pmol/g, respectively.
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