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  • Title: [Cytologic characteristics of bronchial epithelial dysplasia from the viewpoint of the early detection of lung cancer].
    Author: Agamova KA, Tikhomirova EE, Frank GA.
    Journal: Arkh Patol; 1987; 49(7):32-8. PubMed ID: 3662858.
    Abstract:
    Cytomorphologic characteristics of bronchial epithelium have been examined in 58 patients with central lung cancer (42 patients in stage T1N0M0 and 16 in stage T1N1M0 and 84 patients with nonneoplastic diseases (tuberculosis, hamartoma, sarcoidosis, or chronic nonspecific inflammation), using smears from bronchial mucosa, imprints from tissue pieces biopsied on bronchoscopy, scrapings from lesions and surrounding tissues, and transthoracic puncture samples. In 34 of the 58 cancer patients, the changes in bronchial epithelium were categorized as moderate to severe dysplasia. A scheme summarizing malignant transformation of bronchial epithelium is proposed. It is shown that bronchial epithelial dysplasia can be recognized by cytologic examination, which may be used to advantage in screening subjects for early detection of lung cancer.
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