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  • Title: [Nuclear proteins--substrates for cAMP-dependent protein kinase].
    Author: Nesterova MV, Glukhov AI, Aprikian AG, Severin ES.
    Journal: Biokhimiia; 1987 Jul; 52(7):1150-3. PubMed ID: 3663752.
    Abstract:
    The phosphorylation of nuclear proteins of porcine brain cAMP-dependent protein kinase was studied. Some nuclear proteins after extraction from the nuclei served as substrates for protein kinase. Lysine-rich histones H1, H2a and H2b were found to accept phosphate during chromatin phosphorylation by cAMP-dependent protein kinase. Phosphorylation of intact nuclei revealed that in such a system only histone H1 is a substrate for cAMP-dependent protein kinase. In the presence of DNA the histones are phosphorylated by cAMP-dependent protein kinase in a different manner. It was concluded that DNA can determine the accessibility of protein substrates for the catalytic subunit of cAMP-dependent protein kinase.
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