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  • Title: [Effect of naloxone on hypoalgesia in rats exposed to prolonged immobilization stress].
    Author: Kiiatkin EA, Shamakina IIu, Zhukov VN.
    Journal: Biull Eksp Biol Med; 1987 Sep; 104(9):283-5. PubMed ID: 3663908.
    Abstract:
    Significant hypoalgesia (tail-flick reflex at 60 degrees C) was observed in rats during the whole period of 24-hour immobilization in cramped cages, as compared to food-and-water deprived and control animals. This hypoalgesia was not antagonized by naloxone (1 mg/kg), however, the animals periodically receiving the drug during immobilization revealed aggressiveness and significant hypoalgesia after immobilization was discontinued (30-120 min observation).
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