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  • Title: [Hodgkin's nodular paragranuloma (nodular Hodgkin's disease, with lymphocytic predominance): apropos of 29 cases].
    Author: Molina T, Diebold J.
    Journal: Bull Cancer; 1987; 74(4):463-72. PubMed ID: 3663967.
    Abstract:
    The clinical and morphological features of 29 cases of nodular Hodgkin's disease, lymphocyte predominance type (NLPHD) are reported. This disease must be distinguished from other forms of Hodgkin's disease due to its nodular pattern with predominance of small lymphocytes, without sclerosis. Its main feature is the presence of rare lymphocytic histiocytic type Reed-Sternberg cells (LHRS). From a clinical point of view, we observed that the primary lymph nodes involvement are mostly seen in cervical and axillary sites, with a clinical stage I or II at diagnosis, without biological signs of activity and with a good prognosis and long duration of the disease. Two main aspects may be underlined: the frequent relapses after biopsy in lack of treatment, and a possible transformation into a large B cell lymphoma. Immunohistological stainings suggest that LH-RS cells are transformed B cells. NLPHD is a clinicopathological entity which must be currently considered and treated as Hodgkin' disease.
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