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  • Title: The influence of food on the bioavailability of a slow release theophylline preparation.
    Author: Thebault JJ, Aiache JM, Mazoyer F, Cardot JM.
    Journal: Clin Pharmacokinet; 1987 Oct; 13(4):267-72. PubMed ID: 3665325.
    Abstract:
    Food-induced changes in the absorption of Theostat 300, a controlled release formulation of theophylline, have been studied in healthy volunteers. This open, randomised, 3-way, single-dose study involved 12 volunteers who received the drug either while fasting, or with a standardised low-fat (10g), or high-fat (60g) breakfast. Each subject was studied over a 3-week period, with 3 separate days of oral treatment and a 7-day washout period between treatments. The results showed no differences in AUC0-24 and tmax values between the 3 kinds of diet. The only differences observed concerned absorption. Food intake increased Cmax values by 20%. The steady-state peak concentration obtained by means of simulated plasma levels was not influenced by food intake. This slight food-drug interaction of Theostat 300 seemed to be of no clinical significance.
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