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Title: Neurophysiological changes induced by 5-HT reuptake inhibitors in rabbits. Author: Bo P, Patrucco M, Maurelli M, Camana C, Savoldi F. Journal: Farmaco Sci; 1987 Jul; 42(7):505-12. PubMed ID: 3666124. Abstract: The EEGraphic, behavioural and autonomic changes induced by the administration of some inhibitors of serotonin (5-HT) reuptake were evaluated in the rabbit. The drugs examined were: Alaproclate (Ala), Citalopram (Cit), Fluoxetine (Fluo), Fluvoxamine (Fluvo), Indalpine (Ind), Zimelidine (Zim). It seems that all these drugs would act exclusively or prevalently on 5-HT uptake. The changes of the parameters studied were not homogeneous. Some of these drugs (Cit, Zim) induced an EEGraphic and behavioural "arousal" pattern, others (Fluo, Fluvo) a "slow wave sleep" one, others (Ala, Ind) a biphasic one (alteration of the two above-mentioned patterns). The possible hypotheses subtending these data are discussed.[Abstract] [Full Text] [Related] [New Search]