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  • Title: Action of some amides of substituted ethylenediamines on central nervous system.
    Author: Sethi OP, Ismail AM, Bhavsar GC, Trivedi BM, Gulati OD.
    Journal: Indian J Physiol Pharmacol; 1987; 31(2):125-9. PubMed ID: 3666881.
    Abstract:
    Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.
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