These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cell-surface laminin-like molecules and alpha-D-galactopyranosyl end-groups of cloned strongly and weakly metastatic murine fibrosarcoma cells.
    Author: Grimstad IA, Bosnes V.
    Journal: Int J Cancer; 1987 Oct 15; 40(4):505-10. PubMed ID: 3666988.
    Abstract:
    Indications from previous work that cancer cell-surface laminin-like molecules and alpha-D-galactopyranosyl end-groups may contribute to spontaneous metastasis were further investigated. Both moieties are known to mediate cell attachment to various foreign surfaces. Five strongly metastatic and 5 weakly metastatic cell clones from a murine fibrosarcoma were examined for the occurrence of both cell-surface moieties by immunofluorescence flow cytometry and microscopy. None of these clones was rich in laminin-like molecules, which were least strongly expressed by the highly metastatic clones. The alpha-D-galactopyranosyl end-groups were strongly expressed by all strongly metastatic clones and by 2 weakly metastatic clones, but were only weakly expressed by the other weakly metastatic clones. These results indicate that the laminin-like cell-surface molecules are not necessary for spontaneous metastasis formation. However, the alpha-D-galactopyranosyl end-groups may be necessary, but are not sufficient for the cancer cells to form metastases. These carbohydrates are known to occur on the laminin-like molecules. The present results show that they must also exist on other cell-surface molecules.
    [Abstract] [Full Text] [Related] [New Search]